Special issue on stem cells

Special Issue: Mesenchymal Stem Cells

Over the last few years, the mesenchymal stromal compartment of the bone marrow has regained interest. The main reason for this resurgence is the recognition of their immunomodulatory properties and their prominent role in the maintenance and regulation of hematopoiesis. This has simultaneously prompted preclinical and clinical studies trying to take advantage of these properties and, at the sa...

Stem cells and regeneration: a special issue.

Welcome to Development’s special issue on stem cells and regeneration. Developmental biology as a field is undergoing profound transformations. The sequencing of genomes has allowed us to move away from single-gene studies and to focus on a more global understanding of the gene regulatory networks underlying development. Modern imaging techniques now allow the precise quantification of developm...

Special Issue: Inflammatory Bowel Diseases and Intestinal Epithelial Stem Cells

The development of colorectal cancer caused by chronic inflammatory bowel disease (IBD) is the representative example of inflammation-associated carcinogenesis. The mechanism underlying the development of colorectal cancers through chronic inflammation, however, is not known. Activation-induced cytidine deaminase (AID) was originally identified as an inducer of somatic hypermutation in the immu...

Special Issue: Inflammatory Bowel Diseases and Intestinal Epithelial Stem Cells

Adult stem cells have the capacity to self-renew and to regenerate tissues long-term, in both homeostasis and wound repair. Genetic lineage tracing studies have identified two principal stem cell populations in the intestine. One population consists of actively cycling Lgr5+ cells residing at the crypt base. The other population consists of quiescent Bmi1+ cells that largely reside at approxima...

Special Issue